Demenidazole, joalo ka moloko oa pele oa lithethefatsi tse thibelang likokoana-hloko, theko ea eona e tlase e etsa hore e sebelisoe haholo tlhahlobong ea bongaka ba liphoofolo le kalafo.Leha ho le joalo, ka tšebeliso e pharaletseng ea mofuta ona oa lithethefatsi le moloko o batlang o salla morao le oa pele oa nitroimidazole, bothata ba ho hanyetsa lithethefatsi ts'ebetsong bo tla bonahala bo ntse bo eketseha.

01Tšusumetso ea anti-anaerobic

Leha ho le joalo, ts'ebeliso ea eona e pharaletseng tlhahisong ea likhoho e bonahala haholo-holo ho libaktheria tse khahlanong le anaerobic.Lilemong tse mashome tse fetileng, e 'nile ea sebelisoa haholo ho phekola khoho ea necrotic enteritis, enterotoxic syndrome le ho ruruha ha mae a bomme.Leha ho le joalo, kutloisiso ea eona ho li-anaerobes e ntse e mpefala le ho feta.Lebaka ke hore: ka nako e telele nakong e fetileng, tlhekefetso le tšebeliso e sa tloaelehang ea eona e lebisitse ho hanyetsanang le mefuta e sa tšoaneng ea libaktheria tsa anaerobic ho eona selemo le selemo, 'me tlhokomelo e ntse e tsoela pele.E le ho thibela mokhoa ona o mobe oa nts'etsopele, lefapha le nang le bokhoni la bongaka ba liphoofolo le e thibetse ka ho hlaka lilemo tse fetang leshome tse fetileng: e ka sebelisoa feela ho tsoalisong le tlhahisong ea liphoofolo tse sebelisoang haholo, 'me e ka sebelisoa feela liphoofolo tse ruuoang le likhoho, liphoofolo tse ruuoang lapeng le mefuta e meng e sa jeoang.

02Kamano ea mahlale le e utloahalang

Tabeng ea ho lumellana ha tšebeliso e sa utloahaleng ea demenidazole, pele ho tsohle, ha ea lokela ho sebelisoa hammoho le methamphenicol, florfenicol le lithibela-mafu tse ling tsa amido joala, hobane demenidazole e ka baka dysplasia ea moko oa masapo liphoofolong le likhoho, 'me ha e sebelisoa hammoho le tse ka holimo. Amido alcohol, lithibela-mafu, e tla eketsa kotsi ea ho ba le maikutlo a mabe tsamaisong ea mali.

Taba ea bobeli, ha ea lokela ho sebelisoa le ethanol kapa litokisetso tse nang le ethanol e ngata, hobane ho kopana ha tse peli ho tla etsa hore disulfiram itšoare, 'me liphoofolo tse kulang li ka ba le matšoao a itseng a mafu a kelello.Ho phaella moo, tšebeliso ea joala kapa lithethefatsi tse nang le joala bo bongata li lokela ho fokotsoa ka hohle kamoo ho ka khonehang ka hare ho matsatsi a 7-10 ka mor'a ho tlosoa ha lithethefatsi.

Ntlha ea boraro, haholo-holo bakeng sa indasteri ea bongaka ea liphoofolo, pele, ha ea lokela ho kopanngoa le lithethefatsi tsa immunosuppressive, ho seng joalo, demenidazole e ka thibela phello ea mycophenolate mofetil 'meleng.Ea bobeli, e ke ke ea sebelisoa ka li-anticoagulants tsa molomo, tse tla ntlafatsa phello ea anticoagulant ea li-anticoagulants tsa molomo tse kang warfarin, e le hore liphoofolo tse ruuoang lapeng li be le kotsi e eketsehileng ea ho tsoa mali.

Qetellong, sena se haholo-holo indastering ea bongaka ba liphoofolo tse ruuoang lapeng.Ntlha ea pele, e ke ke ea kopanngoa le li-inhibitors tsa enzyme ea sebete.Mohlala, li-inhibitors tsa enzyme ea sebete tse kang cimetidine li ka thibela metabolism ea metronidazole.Ha ho kopantsoe, hoa hlokahala ho lemoha mahloriso a lithethefatsi tsa mali le ho fetola lethal dose hang-hang.Ea bobeli ke hore e ke ke ea sebelisoa le li-inducers tsa enzyme ea sebete.Ha e kopantsoe le li-inducers tsa enzyme ea sebete tse kang phenytoin, metabolism ea demenidazole e tla potlakisa 'me mahloriso a plasma a fokotsehe;Metabolism ea phenytoin le li-inducers tse ling tsa li-enzyme tsa sebete li ile tsa fokotseha 'me mahloriso a plasma a eketseha.

03Tokisetso e ama phello ea pholiso

Hobane demenidazole ka boeona e qhibiliha hanyenyane ka metsing 'me ke lithibela-mafu tse itšetlehileng ka nako, bofokoli ba eona ba lithethefatsi le litšobotsi tsa pharmacodynamic li etsa qeto ea hore "tokisetso e etsa qeto ea ho sebetsa".Hangata re bona ka har'a li-grass-roots hore solubility ea dimenidazole premix sehlahisoa e mpe haholo.Ka mor'a ho eketsa metsi a mangata le ho kopanya ka ho feletseng, ho na le "palo e kholo ea lintho tse sa qhibiliheng" sampuling e ntle ea lehlabathe.Sena ha se "sophistry" ea moetsi ho bitsa bothata ba boleng ba metsi, kapa ka leshano la hore lintho tse sa qhibiliheng ke lisebelisoa le metsoako e meng eo e seng ea lithethefatsi.

Lihlahisoa tsohle tse joalo tsa premixed tsa dimenidazole, ho phaella ho theko e tlaase le e theko e tlaase, li kopane "ha ho na phello".

Ka hona, boholo ba lihoai tsa joang le basebelisi ba lithethefatsi tsa bongaka ba liphoofolo ba lokela ho ela hloko lihlahisoa tsa "boleng bo phahameng" tse nang le lihlahisoa tse lekaneng tsa lithethefatsi le ho qhibiliha hantle ha ho khethoa dimenidazole premix dihlahiswa bakeng sa ho phekoloa mafu a anaerobic tsamaisong ea tšilo ea lijo kapa tsamaiso ea ho ikatisa.Ntle le khetho ea litlhare, mohato oa bohlokoa ka ho fetesisa ke: ho latela sepheo sa 'nete sa ho eketseha ho hanyetsa lithethefatsi, re lokela ho etsa mosebetsi o motle ka ho kopanya, ho sebelisana le ts'ebeliso e kopaneng ea ho hanyetsa lithethefatsi, e le ho matlafatsa le ho bonahatsa "katleho" ea phekolo ea lithethefatsi.