Motsoako oa mantlha: Doxycycline hydrochloride

Thepa: Sehlahisoa sena se botala bo khanyang.

Ts'ebetso ea Pharmacological:

Pharmacodynamics:Sehlahisoa sena ke lithibela-mafu tsa tetracycline tse pharaletseng tse nang le phello e matla ea antibacterial. Libaktheria tse nang le kutloelo-bohloko li kenyelletsa libaktheria tsa Gram-positive tse kang pneumococcus, streptococcus, staphylococcus e itseng, koatsi, tetanus, corynebacterium le libaktheria tse ling tsa Gram-negative tse kang Escherichia coli, Pasteurella, Salmonella, Brucella le Haemophilus, Klebsiterella le memelella. E ka boela ea thibela Rickettsia, mycoplasma le spirochaeta ho isa tekanyong e itseng.

Pharmacokinetics:Ho monya ka potlako, tšusumetso e nyane ea lijo, bioavailability e phahameng. Tšebeliso e sebetsang ea mali e bolokiloe nako e telele, ho phunyeha ha lisele ho matla, kabo e pharaletseng, 'me ho bonolo ho kena ka seleng. Bophahamo bo hlakileng ba ho ajoa lintja ke hoo e ka bang 1.5L/kg. Sekhahla se phahameng sa protheine e tlamang lintja 75% ho isa ho 86%. E sa sebetse ka mokhoa o itseng ke chelation ka maleng, 75% ea tekanyo ea ntja e tlosoa ka tsela ena. Ho ntšoa ha renal ke hoo e ka bang 25% feela, ho ntšoa ha biliary ho ka tlase ho 5%. Halofo ea bophelo ba ntja ke lihora tse 10 ho isa ho tse 12.

Tšebelisano ea lithethefatsi:

(1) Ha e nkuoa ka sodium bicarbonate, e ka eketsa boleng ba pH ka mpeng mme ea fokotsa ho monya le ts'ebetso ea sehlahisoa sena.

(2) Sehlahisoa sena se ka etsa li-complexes tse nang le li-divalent le trivalent cations, joalo-joalo, kahoo ha li nkoa ka calcium, magnesium, aluminium le li-antacids tse ling, lithethefatsi tse nang le tšepe kapa lebese le lijo tse ling, ho monya ha tsona ho tla fokotseha, ho fella ka fokotsa khatello ea mali ea lithethefatsi.

(3) Tšebeliso e tšoanang le li-diuretics tse matla tse kang furthiamide li ka mpefatsa tšenyo ea renal.

(4) E ka kena-kenana le phello ea bactericidal ea penicillin ka nako ea ho ikatisa ea baktheria, e lokela ho qoba tšebeliso e tšoanang.

Lipontšo:

Tšoaetso ea libaktheria tse ntle, libaktheria tse mpe le mycoplasma. mafu a phefumolohang (mycoplasma pneumonia, chlamydia pneumonia, feline nasal lekala, feline calicivirus lefu, canine distemper). Dermatosis, tsamaiso ea genitourinary, tšoaetso ea mala, joalo-joalo.

Tšebeliso le litekanyetso:

Doxycycline. Bakeng sa tsamaiso ea ka hare: tekanyo e le 'ngoe, 5 ~ 10mg ka 1kg boima ba' mele bakeng sa lintja le likatse. E sebelisoa hang ka letsatsi bakeng sa matsatsi a 3-5. Kapa joalokaha ho laetsoe ke ngaka. Ho khothalletsoa ho nka ka mor'a ho fepa le ho noa metsi a mangata ka mor'a tsamaiso ea molomo.

Tlhokomediso:

(1) Ha e khothalletsoe bakeng sa lintja le likatse ka tlase ho libeke tse tharo pele ho pelehi, lactation, le 1 khoeli ea lilemo.

(2) Sebelisa ka hloko ho lintja le likatse tse nang le ho se sebetse ho matla ha sebete le liphio.

(3) Haeba o hloka ho nka li-supplement tsa calcium, li-supplement tsa tšepe, livithamine, li-antacids, sodium bicarbonate, joalo-joalo ka nako e le 'ngoe, ka kopo bonyane nako ea 2h.

(4) E thibetsoe ho sebelisoa le diuretics le penicillin.

(5) E kopantsoe le phenobarbital le anticoagulant e tla ama mosebetsi oa e mong.

Maikutlo a mabe:

(1) Ho lintja le likatse, liphello tse bohloko ka ho fetisisa tsa oral doxycycline ke ho hlatsa, letšollo le ho fokotseha ha takatso ea lijo. Bakeng sa ho fokotsa litlamorao tse mpe, ha ho na phokotso e kholo ea ho monya ha lithethefatsi e ileng ea bonoa ha e nkuoa le lijo.

(2) 40% ea lintja tse phekoloang li bile le keketseho ea li-enzyme tse amanang le sebete (alanine aminotransferase, conglutinase ea motheo). Bohlokoa ba kliniki ba ho eketseha ha li-enzyme tse amanang le ts'ebetso ea sebete ha bo hlake.

(3) Oral doxycycline e ka baka stenosis ea esophageal ka likatse, tse kang matlapa a molomo, e lokela ho nkoa ka bonyane metsi a 6ml, eseng a omme.

(4) Kalafo ka tetracycline (haholo-holo nako e telele) e ka lebisa ho ata ha libaktheria tse sa utloeng bohloko kapa li-fungus (tšoaetso e habeli).

Sepheo: Feela bakeng sa likatse le lintja.

Tlhaloso: 200mg / tablet